Poor Health Spread More VIRUS: Poor Metabolic Health caused VIRAL LOAD

 POOR HEALTH SPREAD MORE VIRUS

Today we're going to talk about Metabolic Health specifically focusing on Viral Load. We're hearing so much in the media about how it's our moral obligation to do certain things because we can then reduce the probability of transmitting pathogens and have lower viral load.

I want to share with you just cure. I curated all of the recent studies that I could find correlating poor metabolic health Dysglycemia also known as insulin resistance or volatile blood sugar and having obesity and how that is correlated with increased viral load and prolonged shedding of pathogens again because we're hearing in the media from all these people.

What is it Kyrieirving, there's basketball players, there's different you know the co-chair for Washington State University WS WSU football team is being ostracized for different choices that he made.

So, we there's a lot of like pressure from individuals and this moral sort of obligation you know it's the moral thing to do to protect other.

 People to do these certain things but i would like to present to you that the argument based upon science remember following the science is what a lot of people are claiming ostensibly to do so we're going to follow the science and talk about how eating donuts, cupcakes and going to the fast food, restaurant for dinner, not exercising, and watching NETFLIX until two in the morning having your phone in your bedroom not managing your stress, how that actually leads to disc glycemia increased levels of inflammation and increase abdominal visceral adiposity that are all correlated with a higher probability of higher viral load and more severe infection.

 That’s why, this is our moral obligation to become metabolically healthy so that when your parents your friends your family your in-laws around the thanksgiving table around christmas holidays you know they're going to give you crap for making different decisions and you need to say and stand up and say look i choose to be healthy it's my moral obligation to not be another cog in health care system to not have the obesity the hypertension.

The Type 2 Diabetes, those are the individuals that are clogging up the healthcare system with all due respect and I know a lot of you are working on your health right now so Im not trying to you know undermine your progress or victim blame i'm just saying it's all of our obligation right to become metabolically healthy to have better blood sugar regulation to have lower body fat because all of these different clinical situations are linked with reduced viral load and the data is overwhelming in fact when I share these studies with you you're going to be like why haven't i seen this yet on CNN or MSNBC why isn't NPR talking about these studies because they have very important public health implications.

 We're going to dive into that we're also going to talk aboutit. you know the importance of probiotics and actually gut health, there's some interesting data on gut health. In this gut lung axis and how if you have intestinal permeability or Dysbiosis in the gut. It might affect your lungs and the permeability in your lungs some interesting new studies that I want to share with you about that and let's start off with this paper, here this was in the British Journal of Medicine; it was an editorial piece the title of the paper is "obesity in covenanting the role of the food industry".Now why is this paper important because these authors go on to talk about there's a lot of correlations here with obesity and fast food consumptions and we now know that you know during the COCA-19 pandemic, there was an increase in food poverty there was food shortages and there's more food shortages coming. We're going to talk about that in a moment but disruptions and supply chains and panic buying cause people to have limited access to fresh real food.

 So, what did they turn to, they turned to Chips, they turned to Flour, they turned to Cookies & Bread, Pasta, and Sugar. Remember sugar was sold out, flour was sold out. So, people were Impulse buying and then there was all these thinly veiled advertising campaigns by the food industry. Remember, we're going to support healthcare workers I remember chick-fil-a in portland oregon was delivering fried chicken, sandwiches to hospital workers and we all we all know the story of krispy kremes donuts don't we so there's been all these incentives for various interventions and they're all from the food industry but there's no outrage. There's outrage for people who don't wear a mask there's outrage you know if you're on the airplane and you happen to have your mask below your nose people will get really irritated with you like what are you doing as they're crushing cheez-its and drinking soda. They're going be mad at you for the mass being below your nose while they willingly weaken their immune system and increase the probability that if they get exposed, they're going to have a more severe disease like it is insane right but yet you have scientists who are pointing this out.

 Where's the outrage, where is the medical community in the media and the politicians like talking about the role that the food industry has had in worsening this virus that should be relatively benign for most people if they didn't have the underlying health conditions.

 

The hypertension  diabetes, the overweightness that is a direct result of consuming the food that the food industry sells which by the way our government subsidizes.

 So, you know those hostess cakes and the all the oreos and all this processed food that cost like 99 cents, whereas an apple or an avocado or a bag of nuts are very expensive; you're like well how is this happening because the Government is subsidizing these ultra processed. you know mono crops, the soy, the corn, the wheat & canola and so forth. So, interesting paper here i think people if they care about saving lives should be really upset with the food industry should be really upset with the politicians who have repeatedly voted .

Yes on the farm bill since 2003. one of those politicians is actually leading this country right now so people should be upset now why are we putting this out because we are now seeing again empty shelves you know supply chain shortages and all this and i don't want us to miss this critical window to favorably change our habits so they're talking about how there might not be turkeys for thanksgiving now because there's a shortage in the the labor for processing these turkeys after the fact so guess what go to craigslist.com.

I reserve my Turkey today not from safeway from a local farmer who happen to have heritage turkeys that are out there just eating bugs and things like that eating what turkeys should be eating.

 Okay you can start growing your own chickens because these these labor shortages i don't know if they're going to resolve themselves anytime soon especially if there's a winter surge and all this sort of stuff which I actually predict that there will be I don't think it will be as bad you know as maybe last winter because there is more immunity but i do believe that there will we're going to see more and more cases and all this so um i don't want us to miss this window of opportunity we shouldn't be relying upon importing food from other countries to serve the citizens of our own country.

            When we have very fertile land here so please friends go to farmers markets call a local rancher farmer try to buy more locally so that when there is you know empty shelves you don't care you're like as long as i have basic necessities you can make your own soap if need be right we can all become a little bit more resourceful so go to craigslist reserve your turkey.

            It's easy to do to process your turkey i've done videos on this um you know i can link them if you'd like a lot of people didn't like those videos they want to buy the meat and be so divorced from the process which i think is part of the problem leads to waste and you know over consumption so we need to be more involved this is what people did um you can do this with your friends and family okay really fascinating paper we're going to dive into this the title this is elevated glucose levels favor stars kobe 2 infection and nocyte response through a complex mechanism known as this hypoxia inducible factor one alpha via glyco glycolysis dependent axis so there's a lot of jargon in this title of the article.

            Here in cell metabolism but to make a long story short the scientists found that the data suggests that and they used monocytes from real humans some were overweight and diabetic And some were not and I found that individuals with high circulating levels of glucose may be more susceptible to infections stars COV2.

            Infections and have viral load so they were able to test this hypothesis by infecting cultured monocytes from isolated obese diabetic patients and compared those to healthy controls and they found that the viral load was dramatically increased. You can see here, it's statistically significantly increased in the  individuals who were overweight and had diabetes. So altogether these data suggest that these data indicate that elevated glucose levels directly promote viral replication and cytokine expression. 

That's we've known now about this immuno metabolism, how our metabolism you know how we curate and redistribute energy in our body, is intimately involved in our body's immune response and aberrant metabolic responses hyperglycemia glycemic variability.

We've talked about the at-home hemoglobin a1c test by biocoach.io phenomenal test to see where you are at in terms of your glucose regulation over the long haul.

 Right we know that there can be ebbs and flows in our fasting glucose but yeah our hemoglobin a1c reflects our baseline or our average glucose level so i will link that below you can save using code hih 10 over at biocoach.io okay we have a lot of stuff here to continue to talk about.

 We're not going to really dive further into diabetes although i will share a few references at the end just so that you have them they're in the notes below of this article but;

This correlation with obesity as we sort of transition gears here to the role that obesity has in terms of having increased levels of viral load this is not no this is not new it's been long known even in influenza outbreaks and so forth that overweight individuals have prolonged viral shedding they have changes in their breath more virus in the breath and more viral variability and it might be I think you know this is really one I want to share this podcast that we should be promoting metabolic health. If we're concerned about new variants emerging because, if you think about more viral load means more viral replication.

So we're hearing so much about well the vaccinated versus the unvaccinated are super spreaders are causing the prolongation of this pandemic but you're like well if you're overweight or you're obese in then you have high viral load.

 Even though you are immunized there's still a lot of virus replicating and just over time through random chance a mutation occurs if it's selectively advantageous and that virus would then have increased transmissibility and so forth so I think there could be something here with regards to overweight metabolic dysfunction and the emergence of new highly transmissible variants and we're going to get to an article here that actually talks about that and that is just another reason that we should all have a moral obligation to eat more real food to exercise to manage our stress to focus on sleep and circadian rhythms.

So I think that's really really important so this is not new i've shared a lot of this is a great image here uh from ryan at all and so they talk about how body fat is reservoir for coronaviruses. it's linked with prolonged viral shedding because of these receptors. 

Now we have a great new electrolyte product coming out that features red men real salt an array of bioavailable minerals like potassium calcium. you have the sodium of course and then also taurine and creatine. This is a multi- ingredient electrolyte combination featuring redmond real salt not this usp salt imported from China. Right we're trying to get a domestic ingredient so, all the minerals by the way friends are derived from utah from albion in ogden utah. And then we also have of course redmond real salt which is down south of provo. So you can support your body's healthy hydration and also optimize athletic performance by going over to myoscience.com that's myoxcince.com, myosciencewithnx.com

When you buy one electrolyte sticks you get the second box 100 disc on it so that's buy one get one free so you have to add two to the shopping cart and the second one will be discounted 100 that only goes through the end of the month that's the end of October.

So take advantage of that pre-sale this formula is a great. It tastes phenomenal. It mixes so easily. i know you're going to dig it. So definitely check that out i will put links below for that as well.

Let's get into this paper right here the title here and we've shared some details of this a few weeks ago, but there was an a recent editorial from a scientist Jonathan Brestoff and so Jonathan Brestoff is an MD Phd and he also has a Master's Degree in Public Health. he's over at Washington University School of Medicine. He wrote an editorial on this paper and the title of this is Clinical Immunological and Virological Sardoscopy to Phenotypes in Obese and Non-Obese Military Health System Beneficiaries.

So the long and short of this studies what they found is in outpatients who had contracted the virus there was an increased viral load in the individuals that had higher levels of body mass index. Now we know that BMI is a very crude sort of height for weight measurement. It doesn't account for lean body mass and differentiate unhealthy fat from healthy tissue.

 However, they did show a very statistically significant correlation and increase with BMI and Viral Load. So, this is important, it's our moral obligation to get healthy friends because we don't want to have high viral love. Now if I can just share a small anecdote before we actually get into what Dr Brestauf talked about.

When I unknowingly was exposed to sarge KOBE 2 ii, the first few days i was around other people. I was and some of these people have comorbidities. I did not get them sick once I started to feel symptomatic. I of course distanced myself. I wore a mask around team members employees things like that got no one sick okay and the virus I had like it was like a day and a half okay and then after that of course I was around other people and no one got sick.

So, I happen to get exposed to this pathogen that is circulating that has caused a lot of people to change how they interact with the world and manage to not get anyone else ill, how is that even possible well turns out that healthier people metabolically healthier people have lower viral load a shorter shedding period and have a greater probability of a mild course of infection. So, there is again for the 10th time it's your moral obligation to improve your health because you want to you don't want to be the one responsible for getting other people sick.

 Do you no i know you don't, so this is why we need to you know exercise go for a 10 minute walk after you eat ride your bike or walk to work or school that's really important okay. So, Jonathan Brestoff goes on to say you know he's making some observations from this really interesting study that i was just alluding to you about the the military recruits and I'm sorry it was like 600 active military members. We shared the details of that study with you early September. So, he goes on to say do these differences in viral load and antibody production reproduce in other populations.

 

for example, in Hispanic People and African, American People etcetera if so this might suggest that the host pathogen interactions are altered in obese patients exposed to sargeras COV2. We've known this for quite a while. We've been talking about this second does higher viral load in obese outpatients have any implications for transmissibility of the virus meaning Higher viral load because you're overweight and it could be that you know fat tissues - we've sort of been talking about is a reservoir for a virus and so forth if the viral load differences found in the study are also seen for emerging variants with higher transmission rates such as delta. The effect could be multiplicative and we've seen that in the south right.

We know that Arkansas, Louisiana, Alabama you know St Louis you know outside of missouri. These were states and regions of the country that were disproportionately at least over the ummer hit hard. Now we know that obesity rates happen to be very high in those in those states as well. So of note the analysis conducted by epsilon was performed before the delta variant was documented- that's kind of interesting thirdly do higher anti-spike protein

antibody concentrations result in better or lasting starch copy to immunity in obese individuals.

 

So it was interesting because of the higher viral load at least initially. There were higher antibody responses right out of the gate, so there's a lot of questions here and I think this is interesting i would encourage you i just took like two paragraphs from the article

it's free it's easy to find i'll put it in the show notes.

I think that's worth reading now before we go on. i just want to make sure that we're all on the same page. This was a very early study that was referenced highly. i think 700 references on this the title of this is detectable serum sars KOBE 2 viral load is closely associated with drastically elevated interleukin-6 level in critically ill Cova-19 patients.

So there's a correlation between the levels of the innate immune system byproduct known as interleukin-6. It's a cytokine, It's an interleukin, it's a chemical messenger that your immune system uses to respond to immunologic triggers such as a viral infection.

Well it turns out that obese individuals individuals that have diabetes chronic smoldering low grade background inflammation like higher levels of C ratchet protein. They have higher levels of Interleukin 6. So, if your Interleukin 6 is already elevated and then you throw in a viral infection influenza whatever guess what you know you're going to potentially have more collateral damage with the so-called cytokine swarm so it's important again it's our moral

obligation to walk to eat real food to eat less processed junk food because this has been known it's a it's a great proxy for viral load so again if you have high levels of baseline interleukin-6 and you can you can measure il-6 um measuring cytokines does get expensive so I frequently measure or have my clients measure c ratchet protein because it's if that is elevated it's highly probable that tnf-alpha and Interleukin-6 and then liquid one Beta and Interferon Gamma like all these other Cytokines will probably be elevated as well meaning that you have some low-grade smoldering inflammation. It usually is a result of under- Exercising and over-consumption of packaged food like. It can be more complicated with other.

You know Co-Infections Lime and Borrelia , mold and this but generally speaking that is  going to take care of a lot of that background inflammation moving more eating less junk food. So that's been known for a long time. Now, let's get into this study, this was there's two more studies. We're going to dive into there's just fascinating here the title of this one is association between upper respiratory tract, viral load comorbidities disease severity and outcomes in patients with stars Cov2 Infections.

So, this was in the journal of infectious diseases. This is not the journal of conspiracy theories research, as you see and look at this table here this is the upper respiratory tract viral low levels and 487 patients as you can see. In this table there's a correlation here between comorbidities and levels of viral load and they show the P value here 0.002.

So, there is a strong correlation with higher viral load linked with these different common comorbid conditions again that are caused by our own diet and lifestyle choices. So the authors go on to say, we studied the upper respiratory tract viral load in one 122 patients with stars COV2 infection diagnosed during the first epidemic wave increase to the best of our knowledge.

This is one of the largest studies looking at Stars Cov2 upper respiratory tract viral load published.

To date to explore in clinical practice both Asymptomatic versus Symptomatic patients and their comorbid conditions, the number of cases allowed us to investigate the association with viral load and specific comorbidities. So these common comorbidities that are that were linked with higher viral load look at obesity.

So, this one here you have you know 12 patients had a super high. You know viral load compared to just three patients with obesity that had low viral load, the same here the significance for hypertension; so 25 patients that were looked and had low viral load versus 37 patients had high viral load and so the p value is 0.002.

So, again this is interesting for the people the friends your family, your coworkers, everyone your employer is like dude come on you got to be like everyone else, you can say well look, I'm working on my health; here the probability of me not having super high levels of a virus could be quite low especially, if you're metabolically healthy, if you exercise, if you take care of yourself. So again it's our moral obligation to be healthy.

This study I thought was interesting. So, exhaled aerosol increases with Covid 19 infection age and obesity. This found a linear correlation between BMI years. They did this mathematical correlation. I don't know why they did this, maybe so they could make the data more clean visually; but they multiplied body mass index by the year and what they found is that there was a significant correlation between increasing BMI years.

So again age matters too right with viral load and that makes sense you know the older you are the weaker your immune system might be your  T cells, might be a little bit there might be more smoldering background, chronic inflammation. So there could be higher viral loads.

 Therefore, it makes sense, so our findings indicate that the capacity of the airway lining mucus to resist breaking up on breathing very significantly between individuals with the trend to increasing with the advance of Covid-19 infection, and body mass index multiplied by H, understanding the source and variance of respiratory droplet generation and controlling it via the stabilization of airway lining mucous surfaces. May lead to effective approaches to reducing COPPER-19 infection and transmission.

 You know figuring out well how can we lower BMI, we could lower BMI by encouraging people to walk, encouraging people make their food from scratch, buy their food from a local farmer, try to make a practice or a goal this this next year to buy food that was grown within a hundred mile radius of your home like it can be challenging but it can be done so, check that out.

 So, here is the graph here and they looked at you know spreader versus super spreader. There's a lot of scientific nuances. You know that we're just really simplifying this here but as you can see there is a linear increase there's a trend the R value. the R squared was 0.98. So, it's you know this is a correlation here, strong correlation. It doesn't tell you the direction of causality but there is much higher viral load found in increasing BMI and increasing age compared to younger individuals. That's why, you can see here the low spreaders, mostly are younger individuals and lower BMI. They have fairly low levels of virus exhaled from their from their mouths.

 So, It’s an important stuff here it's not really talked about in the media again. This might be deemed as fat shaming. This might be deemed as victim blaming and all that but I'd like to just share with you the science. I think this study is quite interesting, so let's get into a little bit more about the gut health you know I'm a huge fan of eating whole real foods.

We know that diverse array of real foods actually support microbiome diversity. We know exercise actually supports gut health we know that not over consuming Alcohol that managing our stress getting a good night's sleep all these things can actually improve the integrity of the vessels and also the epithelial tissue in in the gut and that might also affect the lungs.

There's this gut lung axis. So, the title of this paper is obesity and diabetes as comorbidities for COVID-19 underlying mechanisms and the role of viral bacterial interactions. So you can see here there's the non-obese non-diabetic lung and then there's the obese type 2 diabetic lung and you can see here there's a co-infection, there's a Virus and a Bacteria together. The virus is hijacking on this bacterium. We've seen this co-infection thing go on where some people might get covered but then they get a bacterial lung infection Pneumonia that could be underlying dysbiosis.

So various studies have actually shown that if you have Dysbiosis, you're more likely to have severe outcomes with covid-19. Now you might say well what is dysbiosis ,dysbus is imbalance in your gut bacteria. Now this could happen for reasons that you have no control over for example how you were born? you know maybe your parents decided to have a C-Section

delivered birthing process maybe, your mom didn't breastfeed you. So you had infant formula, maybe you were given antibiotics because persistent ear infections, you know maybe you've been given proton pump inhibitors because you've acid reflux. You know there's a lot of things that can compromise and alter the integrity of our gut and the levels in the composition of those bacteria but there's a lot of things we can do to improve that you can take probiotics.

you can take Saccharomyces Blurry, the probiotic yeast you can eat whole real foods. you can have more Olives, you can have more fermented foods, you can make your food from scratch processed food, especially having something like french fries pizza, cheeseburgers with bacon and bread and all that highly processed carbs with fat together is a bomb.

You know not only cause dysbiosis but compromise the integrity of your intestinal epithelial tissue which can then potentially lead to you some sort of co-infections; and alter the gut lung axis.

So here we go the Synergistic viral bacterial interactions and the severity of Covid-19. It is already well established that the Microbiota can directly or indirectly impact the outcome and differential viral infection viruses bind to bacteria through Lipopolysaccharide.

We've talked a lot about this especially in my blood belly fat effect, so check that out or Peptidoglycan and this binding can provide an enhanced attachment of the virus to its receptor on the surface of host cells thereby enhancing in its infectivity.

So the idea that the virus can sort of hijack its way into the body like a trojan horse onto bacterial gram-negative bacterial lipopolysaccharide which you all have we all have five grams plus or minus of lps lipopolysarchite is just this appendage on gram-negative bacteria. It really shouldn't be getting into your body in systemic circulation but again if you're eating milkshakes pop-tarts cookies processed foods cheez-its you know chicken nuggets, french fries, then guess what happens you alter the balance of bugs in your gut you compromise that single cell lining called the intestinal epithelial tissue also known as leaky gut; and the viral bacterial sort of trojan horse interaction that we were talking about can cause the absorption of pathogens whether it's sarcoid or other pathogens and that binding can effectively increase  the viral load in the lungs.

As, this paper just said so on the other hand respiratory viruses can promote bacterial pneumonia thereby altering the microbiome in the upper airway tract and promoting bacterial accumulate accumulation in the lower airway tract. So, just really I think this stuff is super fascinating, here is just more text here where is the gut lung access is established as an important determinant of severity in pulmonary diseases.

The role of metabolic endotoxemia and severity of COVID-19 remains poorly investigated nevertheless several groups have reported significant changes in gut microbiome and in lps levels in patients with severe forms of COVID-19 ACE2 receptors that we've talked about on. The surface of fat cells and so forth have a major impact on the composition of the microbiome. So again you're like wow. So hypertensive people might have dysregulated microbiomes because of this H2 receptor. It's fascinating stuff. This paper by the way has wonderful images I'll link it in the show notes. So, H2 receptor modulation by viral infection can significantly influence the content and leakage from the gut.

This is top down and bottom up. It goes both ways, so if you get infected you might and it you know cause more leakage from your intestine, and if you have dysbiotic bacteria in your intestine that can then leak through and cause more inflammation. This is insane okay.

So, they want to say H2 receptor modulation by a viral infection can significantly we talked about that in the gut indeed severe forms of copenhagen were connected with pronounced gastrointestinal symptoms post-mortem analysis of 20 individuals who succumbed to this virus, demonstrated that enterobacteria and enterobactericie were more abundant in the human gut and can release large amount of endotoxin. They were very common also in the lung tissue a cross-sectional analysis of 30 patients with cover 19 to 24 patients with influenza a and 30 matched healthy controls revealed significantly higher abundance of opportunistic pathogens in the gut microbiota of COVID-19 patients.

 So, what's the chicken or what's the egg, I think you got to focus on both right but eating real food maybe eating more fermented foods, compressing your feeding window. Exercise these are all things that are great for gut health in a small prospective study on 19 patients with severe pulmonary forms of COVID-19 bacterial dna and toxins were found in blood samples of almost all individuals whereas over 40 of them had high and over 89 percent had increased endotoxin levels measured with a a very chemiluminescence based endotoxin activity assay.

Remember so, in these individuals there was high levels of bacterial DNA in the blood of individuals who had severe coping; so was it the chicken or the egg you know well. They talk about this gut lung axis so if you have poor gut health then you might have a weakened immunity or immune response in your lungs.

So, we got to focus on health friends, I don't know how many other times i can say it really important stuff. The final image here that we're gonna share in the final this is from a paper titled the relevance of physical activity on and physical fitness on immune defense mitigating disease burden with a focus on covenanting consequences. The differences between being sedentary and being physically active. So, sedentary people have reduced muscle function increased cardiovascular risk factors impaired immune function amino senescence and increased incidence of lung inflammation and bacterial pneumonia they also have increased body fat and all this so that leads to as you can see in this image. It's a more severe viral infections in contrast people who regularly exercise. They're physically active they do yoga, they bike, they walk, and so forth have improved immune responses decreased incidence of various infections whether it's you know upper respiratory tract infections. you know urinary tract infections and much more, they have improved lung function, they have even, they should be really, they should be top news, they have stronger and longer lasting antibody responses to various vaccinations. So the pro-vaccine community should really care about exercise. Unfortunately, they never even talk about it. They have you know exercise can mitigate immunosenescence which is the accumulation of these defective immune cells that release messengers to cause other immune cells to misbehave and also exercise has anti-inflammatory capacity that leads to reduced severity of viral infections.

So much stuff here that is not really being talked about my friends. I don't know why but i do want to thank you for tuning all the way into the very end hopefully you found this information at least somewhat helpful. I think practical eating, more real food exercising, more focusing on your sleep, managing your stress, there's just like four simple things that we can all do. We can encourage our friends and family to do this and again. If we're going to talk about moral responsibility and protecting others.

We need to make sure our own bodies are healthy right that our because you're we talk about like transmitting viruses you have a Microbiome cloud like around you like certain people have dysbiosis. They smell bad that Microbiome cloud can influence other people. This is partly how you know just as a small, you know little thing a lot of people don't know about like babies for example how their Microbiome in their immune system is getting educated by being around family, just touching the skin, breast feeding, on the nipple and being passed around but different family members that social interaction shapes the Microbiome which then shapes the immune system in newborns .

So, this is really important stuff friends. We should spread this message if we really care about public health. so I'm grateful that you're reading all the way at the end. Hopefully, you found this helpful. You should leave a comment below I'd like to read your comments and know how we can help create content that you're interested in, so we will catch you in a future article down the road have an awesome rest of your day bye now.